17 articles - From Saturday Apr 16 2022 to Friday Apr 22 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Nephrol Dial Transplant |
The role of renal resistive index as a prognostic tool in kidney transplantation: a systematic review. RRI likely has a prognostic role in predicting patient outcomes, reflecting patient systemic vascular disease burden rather than graft hemodynamics. Since cardiovascular diseases are a major cause of death and graft loss, RRI may be explored as a non-invasive tool to risk stratify KTRs. |
RCT, clinical trials, retrospective studies, etc…
| Am J Kidney Dis |
Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study. Isolated CAKUT and complicated CAKUT were associated with different maternal diseases. The results may inform clinical management of pregnancy and highlight potential differences in the genesis of isolated and complicated forms of CAKUT. |
| J Am Soc Nephrol |
Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and their Combination in Patients with Chronic Kidney Disease: A Randomized Cross-over Clinical Trial. Albuminuria changes in response to dapagliflozin and eplerenone did not correlate, supporting systematic rotation of these therapies to optimize treatment. Combining dapagliflozin with eplerenone resulted in a robust additive UACR lowering effect. A larger trial in this population is required to confirm long-term efficacy and safety of combined SGLT2 inhibitor and MRA treatment. |
Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function. Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. Further work is needed to determine the domains of cognition most affected by decreased secretory clearance and the mechanisms of these associations. |
| Nephrol Dial Transplant |
Electronic alerts and a care bundle for acute kidney injury - an Australian cohort study. Most hospitalised patients developed stage 1 AKI and developed AKI in the community and remained outside the ICU. The AKI eAlert bundle reduced LOS in most patients with AKI and increased AKI documentation, nephrology consultation rate and cessation of nephrotoxic medications. |
Impact of kidney transplantation in obese candidates: a time-dependent propensity score matching study. Regarding the organ shortage, KT may be questionable for those with a BMI = 35 kg/m². These results do not mean that BMI = 35 kg/m² should be a barrier to KT, but it should be accounted in allocation systems to better assign grafts and maximize the overall life expectancy of ESRD patients. |
Long-term impact of cardiorenal syndromes on major outcomes based on their chronology: a comprehensive French nationwide cohort study. The additional impact of CRS vs isolated HF or CKD on long-term kidney and cardiovascular risk is highly heterogenous, depending of the event considered and CRS chronology. No synergy between HF and CKD could be demonstrated. |
Survival, symptoms and hospitalisation of older patients with advanced CKD managed without dialysis. CKM patients survive a median of 14 months from the time of modality choice and have a lower rate of hospitalisation than dialysis patients. Although the symptom burden in advanced CKD is high, most elderly CKM patients managed through an integrated KSC program can achieve improvement in their symptoms over time. These data might help with SDM. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Kidney Dis |
Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022. In addition, an understanding of therapeutic decisions such as induction and maintenance regimens in the setting of glomerular disease and alteration based on trajectory of disease and subsequent response is imperative. The overarching principle of these strategies of immunosuppression is to achieve a balance of disease mitigation without exposure to inadvertent harm. Special groups such as pregnant women, elderly patients, and patients treated with dialysis are especially susceptible to immunosuppression and thus need highly weighed therapeutic strategies and enhanced surveillance of adverse effects. |
| Kidney Int |
The impact of genetic background on mouse models of kidney disease. Genetically diverse mice, such as the Diversity Outbred mice, allow investigators to study kidney phenotypes with comparable levels of genetic diversity as seen in humans, which yield results that more closely reflect the variation in human disease outcomes due to genetic variation. Hence, embracing the genetic diversity that is present in mice can lead to better translational research methods. Investigators need to always take into consideration that genetic background is a variable that can alter results significantly, and optimization of translational research asks for careful strain selection and more rigorous reporting of the genetic background that is being used in experiment. |
Letters to the editors and authors’ replies
| Am J Kidney Dis |
all remaining publications eg case reports, images of the month, etc…
| J Am Soc Nephrol |
| Kidney Int |
| Nat Rev Nephrol |
| Nephrol Dial Transplant |